PittsburghV1, Main, Exploration, bibRecord, 002113

Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly

Identifieur interne : 002113 ( Main/Exploration ); précédent : 002112; suivant : 002114

Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly

Auteurs : Shana M. Katzman ; Elsa S. Strotmeyer ; Michael A. Nalls [États-Unis] ; Yiqiang Zhao [République populaire de Chine] ; Sean Mooney [États-Unis] ; Nik Schork [États-Unis] ; Anne B. Newman ; Tamara B. Harris [États-Unis] ; Kristine Yaffe ; Steven R. Cummings ; Yongmei Liu ; Gregory J. Tranah

Source :

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences [ 1079-5006 ] ; 2014.

RBID : PMC:4612380

Descripteurs français

KwdFr :
- ADN mitochondrial (génétique), ARN ribosomique 16S (génétique), Composition corporelle, Conduction nerveuse (physiologie), Femelle, Génotype, Humains, Mutation (génétique), Mâle, Nerf fibulaire commun (physiologie), Sujet âgé, Temps de réaction (physiologie), Études de cohortes.
MESH :
- génétique : ADN mitochondrial, ARN ribosomique 16S, Mutation.
- physiologie : Conduction nerveuse, Nerf fibulaire commun, Temps de réaction.
- Composition corporelle, Femelle, Génotype, Humains, Mâle, Sujet âgé, Études de cohortes.

English descriptors

KwdEn :
- Aged, Body Composition, Cohort Studies, DNA, Mitochondrial (genetics), Female, Genotype, Humans, Male, Mutation (genetics), Neural Conduction (physiology), Peroneal Nerve (physiology), RNA, Ribosomal, 16S (genetics), Reaction Time (physiology).
MESH :
- chemical , genetics : DNA, Mitochondrial, RNA, Ribosomal, 16S.
- genetics : Mutation.
- physiology : Neural Conduction, Peroneal Nerve, Reaction Time.
- Aged, Body Composition, Cohort Studies, Female, Genotype, Humans, Male.

Abstract

Background.

Mitochondrial dysfunction is a prominent hallmark of many sensory neuropathies. The purpose of this study was to assess the influence of mitochondrial DNA sequence variation on peripheral nerve function in the population-based Health, Aging, and Body Composition Study.

Methods.

We investigated the role of common mitochondrial DNA variation (n = 1,580) and complete mitochondrial DNA sequences (n = 138) on peroneal motor nerve conduction velocity and amplitude, average vibration detection threshold, and monofilament sensitivity.

Results.

Nominal associations among common mitochondrial DNA variants and haplogroups were identified but were not statistically significant after adjustment for multiple comparisons. Sequence-based approaches were used to identify aggregate variant associations across the 16S rRNA (weighted-sum, p = 2E-05 and variable threshold, p = 9E-06) for nerve conduction velocity. Several of these rare 16S variants occurred at or near sites with earlier disease associations and are also in close proximity to the peptidyl transferase center, which is the catalytic center of the 16S rRNA

Conclusions.

These results suggest that sequence variation related to mitochondrial protein synthesis/assembly is associated with peripheral nerve function and may provide insight into targets for intervention or new clinical strategies to preserve nerve function in late life.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612380

DOI: 10.1093/gerona/glu175
PubMed: 25394619
PubMed Central: 4612380

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Body Composition</term>
<term>Cohort Studies</term>
<term>DNA, Mitochondrial (genetics)</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Mutation (genetics)</term>
<term>Neural Conduction (physiology)</term>
<term>Peroneal Nerve (physiology)</term>
<term>RNA, Ribosomal, 16S (genetics)</term>
<term>Reaction Time (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN mitochondrial (génétique)</term>
<term>ARN ribosomique 16S (génétique)</term>
<term>Composition corporelle</term>
<term>Conduction nerveuse (physiologie)</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mutation (génétique)</term>
<term>Mâle</term>
<term>Nerf fibulaire commun (physiologie)</term>
<term>Sujet âgé</term>
<term>Temps de réaction (physiologie)</term>
<term>Études de cohortes</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Mitochondrial</term>
<term>RNA, Ribosomal, 16S</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mutation</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN mitochondrial</term>
<term>ARN ribosomique 16S</term>
<term>Mutation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Conduction nerveuse</term>
<term>Nerf fibulaire commun</term>
<term>Temps de réaction</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neural Conduction</term>
<term>Peroneal Nerve</term>
<term>Reaction Time</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Body Composition</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Composition corporelle</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Études de cohortes</term>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background.</title>
<p>Mitochondrial dysfunction is a prominent hallmark of many sensory neuropathies. The purpose of this study was to assess the influence of mitochondrial DNA sequence variation on peripheral nerve function in the population-based Health, Aging, and Body Composition Study.</p>
</sec>
<sec><title>Methods.</title>
<p>We investigated the role of common mitochondrial DNA variation (<italic>n</italic>
 = 1,580) and complete mitochondrial DNA sequences (<italic>n</italic>
 = 138) on peroneal motor nerve conduction velocity and amplitude, average vibration detection threshold, and monofilament sensitivity.</p>
</sec>
<sec><title>Results.</title>
<p>Nominal associations among common mitochondrial DNA variants and haplogroups were identified but were not statistically significant after adjustment for multiple comparisons. Sequence-based approaches were used to identify aggregate variant associations across the 16S rRNA (weighted-sum, <italic>p</italic>
 = 2E-05 and variable threshold, <italic>p</italic>
 = 9E-06) for nerve conduction velocity. Several of these rare 16S variants occurred at or near sites with earlier disease associations and are also in close proximity to the peptidyl transferase center, which is the catalytic center of the 16S rRNA</p>
</sec>
<sec><title>Conclusions.</title>
<p>These results suggest that sequence variation related to mitochondrial protein synthesis/assembly is associated with peripheral nerve function and may provide insight into targets for intervention or new clinical strategies to preserve nerve function in late life.</p>
</sec>
</div>
</front>
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<affiliations><list><country><li>République populaire de Chine</li>
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</region>
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<tree><noCountry><name sortKey="Cummings, Steven R" sort="Cummings, Steven R" uniqKey="Cummings S" first="Steven R." last="Cummings">Steven R. Cummings</name>
<name sortKey="Katzman, Shana M" sort="Katzman, Shana M" uniqKey="Katzman S" first="Shana M." last="Katzman">Shana M. Katzman</name>
<name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name>
<name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name>
<name sortKey="Strotmeyer, Elsa S" sort="Strotmeyer, Elsa S" uniqKey="Strotmeyer E" first="Elsa S." last="Strotmeyer">Elsa S. Strotmeyer</name>
<name sortKey="Tranah, Gregory J" sort="Tranah, Gregory J" uniqKey="Tranah G" first="Gregory J." last="Tranah">Gregory J. Tranah</name>
<name sortKey="Yaffe, Kristine" sort="Yaffe, Kristine" uniqKey="Yaffe K" first="Kristine" last="Yaffe">Kristine Yaffe</name>
</noCountry>
<country name="États-Unis"><region name="Maryland"><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
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<name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<name sortKey="Mooney, Sean" sort="Mooney, Sean" uniqKey="Mooney S" first="Sean" last="Mooney">Sean Mooney</name>
<name sortKey="Schork, Nik" sort="Schork, Nik" uniqKey="Schork N" first="Nik" last="Schork">Nik Schork</name>
</country>
<country name="République populaire de Chine"><noRegion><name sortKey="Zhao, Yiqiang" sort="Zhao, Yiqiang" uniqKey="Zhao Y" first="Yiqiang" last="Zhao">Yiqiang Zhao</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly

Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly

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Descripteurs français

English descriptors

Abstract

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